Thursday, February 13, 2020

Osteogenesis Imperfecta Research Paper Example | Topics and Well Written Essays - 1500 words

Osteogenesis Imperfecta - Research Paper Example The bigger amino acid network leads to the formation of steric obstruction that creates a swelling in the collagen structure which consequently affects the contact of molecules with one another as well as the nanomechanics of molecules. As a result of this reaction the body responds by dissolving the deformed structure of collagen because if the body does not do so, the interaction existing between the collagen fibers and hydroxyapatite particles that form the bone is changed making them weak and brittle. Another reason that is suggested for the occurrence of this disease is the state of stress at the collagen fibers; when the stress level changes at the points of mutation, where the bigger cut off pressures lead to rapid failing of fibrils even at medium level. There are a lot of reasons all related to the genes that lead to osteogenesis imperfecta. This disease is generally perceived as hereditary however this is not the case. There are eight different types of osteogenesis imperfe cta, most common being Type 1. ... Hearing impairment in infants Slight protuberance of the eyes Type II The quality as well as the quantity of collagen in this type is poor. Most patients suffering from this type of osteogenesis imperfecta die in the initial years of life due to respiratory breakdown or cerebral hemorrhage. The lungs are underdeveloped due to which the patients face respiratory problems. Deformation of bones and small physique Type II is further classified into type IIA, type IIB and type IIC. Type III The quantity if collagen is sufficient but it is not of the required quality. The deformity of bones is such that sometimes they break eve before birth. Possibility of respiratory problems Short physique, bending of the spinal cord and in some cases the shape of rib cage is spiral Joints are loosened The tone of muscles in the arms and legs is of poor quality Discoloration of sclera which turns it form normal white to blue Hearing problems in early ages of infancy Type IV The quantity of collagen is su fficient but quality is not up to the mark. This type is very much similar to Type I as far as the classification is concerned. The fracture of bones starts in the teenage years Rib cage is barrel shaped which leads to deformation of lungs consequently resulting in respiratory problems. The deformity of bone is mild to medium level. Hearing loss starts from a very early age. Type V This has the same clinical characteristics as that of type IV with interconnected appearance of bones being the basic distinguishing factor. Type VI It has the same clinical characteristics as that of type IV. This stage is distinguished by the fish like appearance of the bones. Type VII This type was discovered in the year 2005

Saturday, February 1, 2020

Employee Law and Relation Assignment Example | Topics and Well Written Essays - 2000 words

Employee Law and Relation - Assignment Example This article analyses the basic requirement or what qualifies to bring a claim for unfair dismissals and reviews the recent judgments on termination of employment contract and leads to a broad understanding of what courts consider fair and unfair dismissals. The law explains employee as a person who is employed to provide services to a firm or company on the continuous basis in return of some compensation, who doesn't provide the same services as a part of the independent business. A contract of the employment consists of express terms and implied terms. Express terms explain the terms agreed between the employer and employee, which includes wages and anything, which is related to it. The express contracted terms may not be written one. The express terms may be found in pay slips, letters given to employees before or after he or she started working or in any letter the employee was asked to sign during the course of work. When a particular employment problem crops up it has to be ascertained that whether the employer is a worker. However, any document like, pay slips, the job advertisement any letter sent by the employer in possession of the employee itself will prove that he or she is a worker of that company. The employee must have 12 months continuous service, there are exceptions to this rule. Even if the employee has less than 12 months service he/she may bring a claim for unfair dismissal if he/she is dismissed for the reasons mention under unfair dismissal clauses. To bring a claim under unfair dismissal act the employee must have worked under a contract of service or employment and must have been dismissed in order to raise a claim. In constructive dismissal, the employee resigns, but claims that his employers conduct towards him was the reason to resign the job. If the employer disputes the dismissal, the onus of proving the dismissal lies with the employee, and then only the claim will continue to the next stage. If the employee qualifies under the unfair dismissals legislation he may bring the claim to The Rights Commissioner or Employment Appeals Tribunal.  Ã‚